Table 3.
Renal Compartment | Individual Descriptor or Category | Suggested Metric | |
---|---|---|---|
Overall assessment for disease category | FSGS versus MCD | FSGS or MCD or MCD-like | |
Histology | Tubulointerstitial | Interstitial edema | Present/absent |
Interstitial eosinophils | Present/absent | ||
Vascular | Arteriosclerosis | 0, none 1+, mild 2+, moderate 3+, severe |
|
Arteriolar hyalinosis | 0, none 1+, mild 2+, moderate 3+, severe |
||
EM | Glomerular | Foot process effacement | 0, 0%–10% 1+, 11%–25% 2+, 26%–50% 3+, 51%–75% 4+, >75% |
Podocyte detachment with newly formed matrix | Present/absent | ||
Condensation of the actin-based cytoskeleton | 0, 0 (none) 1+, ≤50% (focal) 2+, >50% (diffuse) |
||
Electron densities/hyaline material | Present/absent |