Effect of ASSE and metformin on blood glucose levels of STZ-nicotinamide-induced diabetic rats. The values are mean ± SEM (n = 6). Administration of metformin and ASSE significantly reduced the blood glucose levels on day 15 and day 30 assessment. One-way ANOVA [F(4,25) = 37.20, p < 0.001 for day 1; F(4,25) = 24.05, p < 0.001 for day 15; F(4,25) = 25.04, p < 0.001 for day 30] followed by Tukey-Kramer multiple comparisons test. *p < 0.05, **p < 0.01, and ***p < 0.001 as compared to the control group; #p < 0.05, ##p < 0.01, and ###p < 0.001 as compared to the diabetic-induced group.