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. 2022 Jun 16;24(2):520. doi: 10.3892/etm.2022.11447

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Copyright: © Li et al.

This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.

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3-BrPA regulates expression of mitochondria-regulated apoptosis pathway proteins. (A) Expression levels of mitochondria-regulated apoptosis pathway proteins, including Bcl-2, Bax, Cyt-C and Caspase-3 were detected through western blot analysis. (B) Bcl-2 protein expression was decreased, while Bax, Cyt-C and Caspase-3 protein expression was increased following 3-BrPA treatment in TNBC cells (^*P<0.05 vs. control group, the same cell line with 0 µM 3-BrPA). (C) However, in non-TNBC cells, the expression levels of Bcl-2, Bax, Cyt-C and Caspase-3 were not significantly affected. 3-BrPA, 3-bromopyruvic acid; Cyt-C, cytochrome c; TNBC, triple-negative breast cancer.