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. 2022 Jun 16;24(2):521. doi: 10.3892/etm.2022.11449

Figure 4.

Figure 4

FTH1 expression in FaDu cells and the effects of TanIIA. (A) Immunohistochemistry indicated that FTH1 was mainly expressed in the cytoplasm and cell membrane (scale bars, 200 µm). (B) Immunofluorescence analysis indicated the location of FTH1 expression (scale bars, 100 µm). (C) Western blot analysis was used to investigate FTH1 protein expression levels. Compared to normal mucosa, FTH1 was significantly overexpressed in HNSCC, while TanIIA treatment significantly attenuated FTH1 expression. Experiments were repeated three times and run in triplicate. ++P<0.01, compared with the control group (Normal mucosa); **P<0.01, compared with the HNSCC group. HNSCC, head and neck squamous carcinoma; FTH1, ferritin heavy chain 1; Tan IIA, Tanshinone IIA.