TABLE 7.

Summary of the identified active mediators from the data application on MESA study based on 10% FDR using the local FDR approach

Method	Selected mediators	Nearby genes	PIP	${\widehat{\beta }}_{\mathit{\text{mj}}}{\widehat{\alpha }}_{\mathit{\text{aj}}}$ (95% CI)
Neighborhood SES → biomarkers → glucose
GMM-CorrS	cg19515398	EIF2C2	0.97	−0.013 (−0.026, 0.000)
	cg04000940	MYBPC3	0.96	0.016 (0.000, 0.029)
	cg17907003	CD101	0.88	0.016 (0.000, 0.034)
	cg27090988	OGG1	0.84	−0.011 (−0.024, 0.000)

Note: We include the nearby gene, PIP, the posterior estimates ${\widehat{\beta }}_{\mathit{\text{mj}}}{\widehat{\alpha }}_{\mathit{\text{aj}}}$ (ie, the marginal indirect contribution of the jth mediator to the joint NIE) and its 95% credible interval (CI) for each selected CpG site. The one additional finding from GMM-CorrS is marked in blue. The GMM-Potts does not identify any active mediators based on 10% FDR.