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. 2022 Jul 5;22:734. doi: 10.1186/s12885-022-09822-8

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© The Author(s) 2022

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 6 — The function of the SPP1 signaling pathway in melanocytes. Knockdown efficiency of CD44 (A) and SPP1 (B) in melanocytes. C Cell viability was determined 24 h after CD44 and SPP1 knockdown, followed by a CCK-8 assay. Data were normalized to NC. D Immunofluorescence staining using EdU in CD44- and SPP1-silenced melanocytes. Scale bars: 100 μm. E Data were collected from at least five sections, and cell numbers were averaged. F The migration activity of melanocytes transfected with CD44 siRNA or SPP1 siRNA was measured by a Transwell assay. G Data are shown as the mean ± SD of three independent experiments. **, P < 0.01