Table 3.
Association between SUA changes and incident MetS by gender
| Categories | Event/total | Unadjusted model HR (95%CI) P Value |
Model 1 HR (95%CI) P Value |
Model 2 HR (95%CI) P Value |
|||
|---|---|---|---|---|---|---|---|
| Men | |||||||
| Longitudinal absolute changes of SUA | |||||||
| Q1 (< − 32 μmol/L) | 742/4289 | 1 (reference) | 1 (reference) | 1 (reference) | |||
| Q2 (− 32 to < − 6 μmol/L) | 711/4493 | 0.90 (0.81, 1.00) | 0.046 | 1.14 (1.03, 1.27) | 0.012 | 1.14 (1.02, 1.26) | 0.016 |
| Q3 (− 6 to < 15 μmol/L) | 723/4234 | 0.99 (0.89, 1.10) | 0.876 | 1.38 (1.24, 1.53) | < 0.001 | 1.38 (1.24, 1.53) | < 0.001 |
| Q4 (15 to < 42 μmol/L) | 793/4557 | 0.99 (0.90, 1.10) | 0.878 | 1.46 (1.31, 1.62) | < 0.001 | 1.45 (1.30, 1.61) | < 0.001 |
| Q5 (≥ 42 μmol/L) | 873/4399 | 1.10 (1.00, 1.22) | 0.050 | 1.72 (1.55, 1.91) | < 0.001 | 1.70 (1.53, 1.89) | < 0.001 |
| P for trend | 0.007 | < 0.001 | < 0.001 | ||||
| Per 10 units increase | 3842/21972 | 1.01 (1.00, 1.01) | 0.022 | 1.04 (1.03, 1.05) | < 0.001 | 1.04 (1.03, 1.05) | < 0.001 |
| Longitudinal percent changes of SUA | |||||||
| Q1 (< − 8.39%) | 704/4393 | 1 (reference) | 1 (reference) | 1 (reference) | |||
| Q2 (− 8.39% to < − 1.77%) | 738/4399 | 1.03 (0.93, 1.15) | 0.543 | 1.18 (1.07, 1.31) | 0.002 | 1.18 (1.06, 1.31) | 0.002 |
| Q3 (− 1.77% to < 4.37%) | 788/4394 | 1.14 (1.03, 1.26) | 0.014 | 1.41 (1.27, 1.56) | < 0.001 | 1.41 (1.27, 1.56) | < 0.001 |
| Q4 (4.37% to < 12.14%) | 800/4388 | 1.12 (1.02, 1.24) | 0.023 | 1.51 (1.36, 1.68) | < 0.001 | 1.50 (1.35, 1.66) | < 0.001 |
| Q5 (≥ 12.14%) | 812/4398 | 1.10 (1.00, 1.22) | 0.062 | 1.76 (1.58, 1.96) | < 0.001 | 1.74 (1.56, 1.94) | < 0.001 |
| P for trend | 0.018 | < 0.001 | < 0.001 | ||||
| Per 10% increase | 3842/21972 | 1.03 (1.00, 1.05) | 0.027 | 1.16 (1.13, 1.19) | < 0.001 | 1.16 (1.13, 1.19) | < 0.001 |
| Women | |||||||
| Longitudinal absolute changes of SUA | |||||||
| Q1 (< − 28 μmol/L) | 264/4328 | 1 (reference) | 1 (reference) | 1 (reference) | |||
| Q2 (− 28 to < − 5 μmol/L) | 290/4422 | 1.05 (0.89, 1.25) | 0.541 | 1.38 (1.17, 1.64) | < 0.001 | 1.40 (1.18, 1.66) | < 0.001 |
| Q3 (− 5 to < 14 μmol/L) | 285/4360 | 1.03 (0.87, 1.21) | 0.772 | 1.47 (1.23, 1.75) | < 0.001 | 1.47 (1.23, 1.75) | < 0.001 |
| Q4 (14 to < 37 μmol/L) | 338/4516 | 1.14 (0.97, 1.33) | 0.120 | 1.68 (1.41, 1.99) | < 0.001 | 1.63 (1.37, 1.94) | < 0.001 |
| Q5 (≥ 37 μmol/L) | 442/4578 | 1.36 (1.17, 1.58) | < 0.001 | 2.03 (1.73, 2.39) | < 0.001 | 1.94 (1.65, 2.28) | < 0.001 |
| P for trend | < 0.001 | < 0.001 | < 0.001 | ||||
| Per 10 units increase | 1619/22204 | 1.03 (1.02, 1.04) | < 0.001 | 1.05 (1.04, 1.07) | < 0.001 | 1.05 (1.04, 1.06) | 0.011 |
| Longitudinal percent changes of SUA | |||||||
| Q1 (< − 10.19%) | 242/4441 | 1 (reference) | 1 (reference) | 1 (reference) | |||
| Q2 (− 10.19 to < − 1.90%) | 316/4442 | 1.29 (1.09, 1.52) | 0.003 | 1.48 (1.25, 1.76) | < 0.001 | 1.44 (1.22, 1.71) | < 0.001 |
| Q3 (− 1.90% to < 5.75%) | 319/4443 | 1.26 (1.06, 1.49) | 0.007 | 1.50 (1.26, 1.78) | < 0.001 | 1.49 (1.26, 1.77) | < 0.001 |
| Q4 (5.75% to < 15.29%) | 358/4435 | 1.38 (1.17, 1.62) | < 0.001 | 1.79 (1.51, 2.13) | < 0.001 | 1.70 (1.43, 2.01) | < 0.001 |
| Q5 (≥ 15.29%) | 384/4443 | 1.37 (1.16, 1.61) | < 0.001 | 2.13 (1.79, 2.53) | < 0.001 | 2.01 (1.69, 2.39) | < 0.001 |
| P for trend | < 0.001 | < 0.001 | < 0.001 | ||||
| Per 10% increase | 1619/22204 | 1.05 (1.02, 1.08) | < 0.001 | 1.16 (1.12, 1.19) | < 0.001 | 1.15 (1.11, 1.18) | < 0.001 |
SUA serum uric acid, MetS metabolic syndrome, CI confidence interval, TC total cholesterol, LDL-C low-density lipoprotein cholesterol, SCr serum creatinine
Model 1: adjusted for baseline age, smoking status, drinking status, SUA
Model 2: adjusted for baseline TC, LDL-C, and SCr, in addition to covariates in Model 1