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. 2022 Jul 6;20:302. doi: 10.1186/s12967-022-03510-8

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© The Author(s) 2022

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 1 — Spatial transcriptomics (ST) to identify intra-tumor heterogeneity in colorectal cancer. A Spatial images of unsupervised clustering results (left) and hematoxylin–eosin staining (H&E) sections annotations (right). B, C UMAP plot of cell types and PCA clustering result profiled in the presenting work. D The expression level of cell markers across different morphological regions through the Dot plot. E Spatial plots show the spatial expression pattern of fibroblast and tumor markers (COL1A1, EPCAM) in this study. F Heatmap of cell-type scores estimated by ssGSEA