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. 2022 Jul 6;20:302. doi: 10.1186/s12967-022-03510-8

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© The Author(s) 2022

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 5 — iCAFs is associated with clinical prognosis and immune infiltration. A–D Box plots show the correlations between iCAFs and clinicopathologic features. E, F K-M survival plots show that high iCAFs predicted poor prognosis in TCGA COADREAD cohort, OS: overall survival, DSS: disease specific survival. G Forest map shows that iCAFs is an independent prognostic factor for OS. H Immunohistochemical analysis of PDGFRA expression in colorectal cancer or para-carcinoma tissues. I, J The diagrams show the relationships between iCAFs and immune score as well as stromal score. p value < 0.05 was considered as cut-off criteria