Table 4.

Correlation analysis between eIF6 and relate genes and markers of adaptive immunity cells in ESCA

Description	Genemarkers	TIMER (n = 184)				GEPIA2 (n = 181)
		Purity		None
		Cor	p	Cor	p	Cor	p
CD8 + Tcell	CD8A	− 0.136	0.067	− 0.144	0.050	− 0.130	0.086
	CD8B	− 0.070	0.347	− 0.087	0.241	− 0.110	0.140
T cell	CD3D	− 0.108	0.147	− 0.114	0.121	− 0.170	*
(general)	CD3E	− 0.143	0.055	− 0.155	*	− 0.200	*
	CD2	− 0.167	*	− 0.178	*	− 0.190	*
Bcell	CD19	− 0.009	0.906	− 0.026	0.728	− 0.120	0.120
	CD20 (MS4A1)	− 0.051	0.496	− 0.070	0.345	− 0.100	0.160
	CD138 (SDC1)	− 0.084	0.262	− 0.054	0.466	− 0.044	0.550
	CD23 (FCER2)	− 0.004	0.960	− 0.019	0.792	− 0.110	0.130
Th1	T-bet (TBX21)	− 0.162	*	− 0.172	*	− 0.190	*
	STAT4	− 0.242	*	− 0.242	*	− 0.200	*
	STAT1	− 0.097	0.195	− 0.089	0.229	0.003	0.960
	IFN-γ (IFNG)	− 0.094	0.207	− 0.090	0.222	− 0.150	*
	TNF-α (TNF)	− 0.029	0.695	− 0.008	0.913	− 0.028	0.710
Th2	GATA3	− 0.124	0.097	− 0.117	0.113	− 0.092	0.220
	STAT6	− 0.038	0.612	− 0.037	0.616	0.057	0.440
	STAT5A	− 0.072	0.334	− 0.081	0.276	− 0.063	0.390
	IL13	− 0.116	0.119	− 0.112	0.130	− 0.140	0.061
Tfh	BCL6	− 0.382	*	− 0.348	*	− 0.270	*
	IL21	− 0.112	0.132	− 0.106	0.152	− 0.180	*
	CD278 (ICOS)	− 0.225	*	− 0.215	*	− 0.190	*
	CXCL13	− 0.169	*	− 0.174	*	− 0.170	*
Th17	STAT3	− 0.085	0.257	− 0.073	0.321	− 0.042	0.570
	IL17A	0.226	*	0.205	*	0.053	0.480
Treg	FOXP3	− 0.245	*	− 0.239	*	− 0.210	*
	CCR8	− 0.260	*	− 0.266	*	− 0.230	*
	STAT5B	− 0.166	*	− 0.160	*	− 0.084	0.260
	TGFβ (TGFB1)	− 0.122	0.103	− 0.091	0.217	− 0.076	0.310
	CD25 (IL2RA)	− 0.255	*	− 0.248	*	− 0.180	*
T cell exhaustion	PD-1 (PDCD1)	− 0.116	0.121	− 0.120	0.104	− 0.130	0.078
	CTLA4	− 0.205	*	− 0.205	*	− 0.200	*
	LAG3	− 0.158	*	− 0.157	*	− 0.085	0.250
	TIM-3 (HAVCR2)	− 0.250	*	− 0.236	*	− 0.230	*
	GZMB	− 0.108	0.149	− 0.108	0.144	− 0.099	0.180

TAM, tumor associated macrophage; Cor, R value of Spearman’s correlation. Purity, correlation adjusted by purity. *P < 0.05. None, correlation without adjustment