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. 2022 Jul 6;20:298. doi: 10.1186/s12967-022-03496-3

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© The Author(s) 2022

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 5 — In vitro studies revealed that overexpression of HHLA could significantly increase the cellular migration abilities by using wound-healing assay and transwell assay. A and B The wound-healing assay revealed that in 786-O cells, after depletion of METTL3, overexpression of HHLA2 could significantly increase the cellular migration abilities (LV-METTL3-shRNA v.s. LV-METTL3-shRNA + LV-HHLA2^OE, P < 0.01). C and D The wound-healing assay revealed that in ACHN cells, after depletion of METTL3, overexpression of HHLA2 could significantly increase the cellular migration abilities (LV-METTL3-shRNA v.s. LV-METTL3-shRNA + LV-HHLA2^OE, P < 0.01). E and F The transwell assay results confirmed that, in both 786-O and ACHN cells, overexpression of HHLA2 could significantly increase the cellular invasion abilities (LV-METTL3-shRNA v.s. LV-METTL3-shRNA + LV-HHLA2^OE, P < 0.01 respectively). Un-paired t test was used as needed. ^**P < 0.01, ^***P < 0.001