Table 2.
Etiology of biliary obstruction and various humoral parameters, median (25%-75%)
|
Parameter
|
Benign etiology (n = 34)
|
Malignant etiology (n = 21)
|
P
value1
|
Controls (n = 40)
|
P
value2
|
| CRP (mg/L) | 13.1 (6.6-19.6) | 6.3 (2.9-11.3) | 0.001 | 2.3 (0.9-3.4) | < 0.001 |
| ES (mm/h) | 25 (13.0-31.5) | 25 (12.0-41.0) | NS | 6.5 (4-13.2) | < 0.001 |
| Leukocytes (× 109) | 6.7 (4.9-8.9) | 6.7 (3.9-7.0) | NS | 5.9 (5.5-7.2) | NS |
| Hemoglobin (g/L) | 141 (123.8-147.0) | 125 (113.5-134.5) | 0.002 | 140 (135.0-156.5) | < 0.001 |
| Thrombocytes (× 109) | 220 (197.2-248.3) | 178 (113.5-289.5) | NS | 241 (188.5-289) | 0.042 |
| Bilirubin (mmol/L) | 85.3 (51.9-183.3) | 270 (145-359.8) | < 0.001 | 12.1 (10.7-14.0) | < 0.001 |
| AST (U/L) | 123 (84.0-212.3) | 155.0 (78.0-186.0) | NS | 19.0 (18.0-23.8) | < 0.001 |
| ALT (U/L) | 337.5 (84.8-547.5) | 232 (114-355.5) | NS | 16.0 (14.0-21.8) | < 0.001 |
| GGT (U/L) | 448 (333.8-602.8) | 396.0 (243.5-892.5) | NS | 18.0 (16.0-25.8) | < 0.001 |
| ALP (U/L) | 287.5 (261.8-418.5) | 281.0 (243.5-434.0) | NS | 83.5 (63.5-94.3) | < 0.001 |
| Blood glucose (mmol/L) | 5.8 (5.2-6.7) | 6.7 (6.3-7.6) | 0.006 | 5.3 (4.8-5.6) | < 0.001 |
| Creatinine (mmol/L) | 89.0 (82.0-110.5) | 105.0 (80.5-123.5) | NS | 84.5 (76.0-104.0) | 0.032 |
| Calcium (mmol/L) | 2.3 (2.2-2.5) | 2.4 (2.3-2.4) | NS | 2.4 (2.3-2.4) | NS |
| LDH (U/L) | 187.5 (152.8-213.5) | 196.0 (175.0-232.5) | NS | 158.0 (147.3-188.0) | 0.004 |
| Cholesterol (U/L) | 5.2 (4.9-6.8) | 5.4 (4.7-8.4) | NS | 6.0 (5.5-6.6) | 0.033 |
| Triglycerides (mmol/L) | 1.9 (1.1-2.3) | 2.4 (1.9-3.1) | 0.005 | 1.3 (1.1-1.6) | < 0.001 |
| Albumin (g/L) | 37.8 (32.9-41.0) | 36.0 (33.1-39.3) | NS | 43.0 (42.0-44.1) | < 0.001 |
| Ghrelin (pg/mL) | 1449.5 (1124.5-2398.8) | 1646.0 (1010.0-4179.0) | NS | 533.5 (368.5-931.5) | < 0.001 |
| CCK (pg/mL) | 291.7 (160.9-411.7) | 191.0 (142.6-218.5) | NS | 153.1 (72.3-262.4) | < 0.001 |
| IL-6 (pg/mL) | 7.0 (5.0-18.3) | 9.0 (80-11.0) | NS | 2.5 (2.0-4.0) | < 0.001 |
| TNF-α (pg/mL) | 11.0 (8.0-12.0) | 12.0 (10.5-14.5) | NS | 6.0 (5.0-7.0) | < 0.001 |
1
Mann-Whitney U test (comparison between benign and malignant groups).
2
Kruskal-Wallis test (comparison between all three groups).
Values are presented as median (Q1-Q3). AST: Aspartate aminotransferase; ALT: Alanine aminotransferase; ALP: Alkaline phosphatase; CRP: C-reactive protein; CCK: Cholecystokinin; ES: Erythrocyte sedimentation rate; GGT: Gamma-glutamyl transferase; LDH: Lactate dehydrogenase; NS: Not significant; IL-6: Interleukin 6; TNF-α: Tumor necrosis factor α.