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. 2022 Jun 16;10(17):5551–5565. doi: 10.12998/wjcc.v10.i17.5551

Table 4.

Effects of biliary drainage


During biliary obstruction (n = 55)
48 h after drainage (n = 55)
28 d after drainage (n = 55)
P value1
Bilirubin (mmol/L) 145 (63.9-230.7) 88.5 (38.75-190.5) 25 (18.85-38.7) < 0.001
ALT (U/L) 133 (78-194) 91.5 (63.75-144.25) 30 (23-46.5) < 0.001
GGT (U/L) 278 (103-421) 194 (103.25-267.25) 36 (28-64) < 0.001
ALP (U/L) 448 (288.5-612.5) 382.5 (184-606.5) 85 (61-111) < 0.001
AST (U/L) 284 (260.5-382) 281.5 (231.75-429.25) 123 (103.5-166) < 0.001
CRP (mg/L) 10.0 (5.8-14.1) 17.9 (5.9-26.8) 8.3 (2.5-17.3) 0.009
IL-6 (pg/mL) 9 (6-13) 11 (7-22) 9 (5-21.5) 0.332
TNF-α (pg/mL) 11 (8.5-13) 10 (9-12) 10 (8-12.5) 0.088
Ghrelin (pg/mL) 1549 (1079.5-2400.5) 1648.5 (1137.25-2767) 1612 (891.5-2962) 0.552
Cholecystokinin (pg/mL) 213.0 (161.0-380.7) 266.0 (203.0-400.5) 235.0 (158.0-433.0) 0.03
Albumin (g/L) 37.1 (33.0-40.8) 35.0 (32.4 -38.0) 38.0 (35.0-42.0) < 0.001
Appetite (VAS) 4 (2-6) 6 (4-8) 7 (6-9) < 0.001
BMI (kg/m2) 24.5 (21.3-28.2) 24.4 (20.6-27.9) 24.9 (21.2-26.8) < 0.001
Body fat (%) 23 (17-25) 23 (17-24) 23 (19-25) 0.002
NRS 2002 3.0 (2.0-4.0) 3.5 (2.0-4.0) 0.0 (0.0-4.0) < 0.001
1

Friedman test across three observations.

Values are presented as median (Q1-Q3); ALT: Alanine aminotransferase; GGT: Gamma-glutamyl transferase; ALP: Alkaline phosphatase; AST: Aspartate aminotransferase; CRP: C-reactive protein; IL-6: Interleukin 6; TNF-α: Tumor necrosis factor α; VAS: Visual analog scale; BMI: Body mass index; NRS: Nutritional risk screening.