Table 2.

Histopathologic findings of kidney biopsies.

Parameters	n	Patients
Histopathology, n (%)
Mesangial proliferation	929	305 (32.8%)
Subendothelial immune complex deposition	793	33 (4.2%)
Subepithelial immune complex deposition	809	332 (41%)
Endocapillary proliferation	589	33 (5.6%)
Exudative glomerular changes	555	25 (4.5%)
Increased capillary basal membrane thickness	968	908 (93.8%)
Interstitial inflammation	941	526 (55.9%)
Interstitial fibrosis
Absent		515 (54.4%)
Grade 1 (<25%)	946	324 (34.2%)
Grade 2 (25–50%)		82 (8.7%)
Grade 3 (>50%)		25 (2.6%)
Vascular changes	946	323 (34.1%)
Tubular atrophy
Absent		501 (52.6%)
Grade 1 (<25%)		374 (39.3%)
Grade 2 (25–50%)	952	59 (6.2%)
Grade 3 (>50%)		18 (1.9%)
Number of glomerular changes, median (min–max)
Total glomeruli in biopsy sample	974	15 (1–98)
Global sclerotic	913	1 (0–24)
Segmental sclerotic	825	0 (0–18)
Crescentic glomeruli	816	0 (0–10)
Cellular crescents	584	0 (0–3)
Fibrocellular crescents	584	0 (0–3)
Fibrous crescents	584	0 (0–3)
Immunofluorescence microscopy findings, n (%)	928
IgG
Negative		64 (7%)
(+)	915	72 (7.9%)
(++)		200 (21.9%)
(+++)		579 (63.3%)
IgM
Negative		671 (74.6%)
(+)	899	152 (16.9%)
(++)		56 (6.2%)
(+++)		20 (2.2%)
IgA
Negative		756 (83.7%)
(+)	903	101 (11.2%)
(++)		30 (3.3%)
(+++)		16 (1.8%)
C3
Negative		281 (31.2%)
(+)	901	259 (28.7%)
(++)		206 (22.9%)
(+++)		155 (17.2 %)
C1q
Negative		716 (88.4%)
(+)	810	63 (7.8%)
(++)		18 (2.2%)
(+++)		13 (1.6%)
Kappa
Negative		148 (30.4%)
(+)	487	90 (18.5%)
(++)		123 (25.3%)
(+++)		126 (25.9%)
Lambda
Negative		146 (30%)
(+)	486	90 (18.5%)
(++)		124 (25.5%)
(+++)		126 (25.9%)
Fibrinogen
Negative		677 (92.7%)
(+)	730	37 (5.1%)
(++)		11 (1.5%)
(+++)		5 (0.7%)

The data were expressed as median (minimum: maximum) and n (%).