Table 4.
Comparison of patients with eGFR values below and over 60 mL/min.
| Parameters | Patients with eGFR <60 (n = 155) | Patients with eGFR >60 (n = 774) | p Value |
|---|---|---|---|
| Age (years) | 55.3 ± 13.2 | 44.7 ± 13.8 | <0.001 † |
| Comorbidities | |||
| Hypertension (n = 906) | 99 (64.7%) | 225 (29.9%) | <0.001* |
| Diabetes mellitus (n = 905) | 25 (16.4%) | 78 (10.4%) | 0.036* |
| Systolic blood pressure (mm/Hg) | 137.5 (122.5–148.6) | 130 (120–140) | <0.001 § |
| Diastolic blood pressure (mm/Hg) | 82.5 (73.5–91.5) | 80 (70–83) | 0.001 § |
| Biochemistry | |||
| Glucose (mg/dL) | 95.5 (86.3–107) | 93 (85–104) | 0.024 § |
| Blood urea nitrogen (BUN) (mg/dL) | 31 (25–37.5) | 15 (11–18) | <0.001 § |
| Urine Protein(mg/24 h) | 6917 ± 441 | 7169 ± 259 | 0.651 |
| Uric acid (mg/dL) | 6.9 ± 1.7 | 5.7 ± 1.6 | <0.001 † |
| Total cholesterol (mg/dL) | 259 (186–322) | 280 (228–335) | <0.001 § |
| Triglyceride (mg/dL) | 182 (128–243) | 209 (145–321) | 0.010 § |
| HDL-cholesterol (mg/dL) | 54 (39–72) | 50 (41–59) | 0.006§ |
| LDL-cholesterol (mg/dL) | 161 (131–210) | 175 (137–237) | <0.001 § |
| Total protein (g/dL) | 5.6 ± 1.0 | 5.3 ± 1.1 | 0.002 † |
| Albumin (g/dL) | 3.0 ± 0.8 | 2.7 ± 0.9 | 0.003 † |
| Hemoglobin (g/dL) | 11.8 ± 1.9 | 13.5 ± 1.7 | <0.001 † |
| Hematocrit (%) | 34 (31.3–37.5) | 40 (37–44) | <0.001 § |
| Histopathology n (%) | |||
| Mesangial proliferation (n = 878) | 57 (39.0%) | 222 (30.3%) | 0.041* |
| Interstitial inflammation (n = 891) | 112 (75.2%) | 377 (50.8%) | <0.001* |
| Interstitial fibrosis (n = 892) | |||
| Absent | 52 (34.7%) | 438 (59.0%) | <0.001* |
| Grade 1 (<25%) | 55 (36.7%) | 249 (33.6%) | |
| Grade 2 (25–50%) | 32 (21.3%) | 43 (5. 8%) | |
| Grade 3 (>50%) | 11 (7.3%) | 12 (1.6%) | |
| Vascular changes (n = 890) | 85 (58.2%) | 217 (29.2%) | <0.001** |
| Tubular atrophy (n = 897) | |||
| Absent | 46 (30.5%) | 432 (57.9%) | <0.001* |
| Grade 1 (<25%) | 66 (43.7%) | 283 (37.9%) | |
| Grade 2 (25–50%) | 32 (21.2%) | 22 (2.9%) | |
| Grade 3 (>50%) | 7 (4.6%) | 9 (1.2%) | |
| Number of glomerular changes median (min–max) | |||
| Total glomeruli in biopsy sample | 13.5 (2–61) | 17 (1–98) | 0.002 § |
| Global sclerotic | 2 (0–24) | 0 (0–18) | <0.001 § |
| Segmental sclerotic | 0 (0–8) | 0 (0–18) | <0.001 § |
| Crescentic glomeruli | 0 (0–2) | 0 (0–5) | 0.036 § |
CKD-EPI: chronic kidney disease epidemiology study; GFR: glomerular filtration rate
*Chi-squared tests;
**Fisher’s exact test;
§Mann–Whitney U test;
†Independent samples t-test.
Post hoc analysis with Bonferroni correction showed the following: in interstitial fibrosis variable, significant difference was between grade 1 vs. grade 2, and grade 1 vs. grade 3, and absent vs. grade 1, in tubular atrophy variable: grade 1 vs. grade 2, and grade 1 vs. grade 3, and absent vs. grade 1. Bold values are statistically significant at p < 0.05.