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. Author manuscript; available in PMC: 2022 Jul 6.
Published in final edited form as: Drug Dev Res. 2003 Apr;58(4):330–339. doi: 10.1002/ddr.10168

Fig. 5.

Fig. 5.

Induction of apoptosis in HL-60 (human leukemia) cells upon 48-h exposure to nucleoside analogs selective for the A3 AR [Kim et al., 2002b]. These included the full A3 AR agonist Cl-IB-MECA, low efficacy A3 AR partial agonist MRS1760, and full A3 AR agonist MRS1898 (each 30 μM). Evidence indicates that in this system, CL-IB-MECA at this high concentration is not acting through an AR-mediated mechanism.