. Author manuscript; available in PMC: 2022 Jul 6.

Published in final edited form as: J Chromatogr B Analyt Technol Biomed Life Sci. 2009 Jun 21;877(24):2593–2597. doi: 10.1016/j.jchromb.2009.06.023

Table 2.

Estimated pharmacokinetic parameters after oral administration of mitragynine (20 mg/kg) to Wistar rats.

Parameter	Unit	Mean	S.E.

C _max	(ng/mL)	423.68	61.79
t _max	(h)	1.26	0.20
t _1/2a	(min)	16.97	5.70
K _a	(1/min)	0.04	0.01
t _1/2	(h)	3.85	0.51
K _el	(1/h)	0.18	0.02
AUC^0–∞	(μg min/mL)	188.98	1940
V _d/f	(L/kg)	37.90	5.41
C1/f	(L/h kg)	6.35	0.43

C_max: peak plasma concentration; t_max: time to reach C_max: t_1/2a, absorption half-life; K_a: absorption rate constant; t_1/2: elimination half-life; K_el: elimination rate constant; AUC^0–∞: area under the plasma concentration-time curve; V_d/f: apparent volume of distribution; Cl/f: apparent total clearance: S.E.: standard error.