Table 1.
Clinical trials with the NAD+ precursors in elderly people with or without diseases
| Target molecule, therapy applied | Disease | Status/results | Reference |
|---|---|---|---|
| NAD+-precursors nicotinic acid, nicotinamide, and tryptophan | Aging | In physically compromised older adults, the dietary supplements did not alter the mitochondrial function or skeletal muscle function | NCT03310034 [196] |
| NAD3 (an over-the-counter dietary supplement | Aging | Yet to publish | NCT04276948 |
| MIB-626 (Nicotinamide mononucleotide (NMN) | Alzheimer’s Disease, Dementia | Not yet recruiting | NCT05040321 |
| Nicotinamide riboside (NR) | Aging | Yet to publish | NCT02950441 |
| Niagen (Nicotinamide riboside, NR) | Mild Cognitive Impairment | Recruiting | NCT03482167 |
| Deuterated nicotinamide (D4-NAM) IV infusion | To study the impact of lifestyle, aging on the rate of NAD synthesis | Recruiting | NCT04905446 |
| Nicotinamide riboside (NR) | To study the role of dietary NR supplementation on the muscle functions in older people | Recruiting | NCT04691986 |
| Nicotinamide riboside (NR) | Role of NR on the skeletal function and metabolic function in elderly people | Recruiting | NCT03818802 |
| Nicotinamide riboside (NR) | Role of NR on the brain function, blood flow in elderly people with mild cognitive impairment | Yet to publish | NCT02942888 |
| Nicotinamide riboside (NR) | Role of NR in metabolism and mitochondrial function in elderly people | Recruiting | NCT04907110 |
| Nicotinamide riboside (NR) | To study whether NR supplementation can shorten the recovery time from acute injury | Recruiting | NCT04110028 |
| Nicotinamide | Alzheimer’s Disease | Recruiting | NCT03061474 |
| Nicotinamide | Alzheimer’s Disease | Yet to publish | NCT00580931 |
| Niacin | Parkinsons Disease | Active, not recruiting | NCT03808961 |
| Nicotinamide riboside (NR) | To study the role of NR on vascular function in young and older people following high-fat diet intake | Yet to publish | NCT03501433 |
| Nicotinamide riboside (NR) | To assess the arterial stiffness in middle age and elderly people | Recruiting | NCT03821623 |
| NMN | Aging | Yet to publish | NCT04228640 |
| Nicotinamide riboside (NR) | Hypertension in elderly people | Recruiting | NCT04112043 |
| Niagen | Aging, cognitive impairment | Active, not recruiting | NCT04078178 |
| Niagen | Aging, age-associated physiological dysfunction | Yet to publish | NCT02921659 |