Table 2:
Reason for diflunisal discontinuation
| Subject ID | Diflunisal duration of treatment (years) | Reason for discontinuation |
|---|---|---|
| 01 | 5.8 | Reduction in creatinine clearance |
| 02 | 0.4 | Fatigue |
| 03 | 1.0 | Reduction in creatinine clearance |
| 04 | 8.4 | Enrollment in another clinical trial |
| 05 | 4.8 | Reduction in creatinine clearance |
| 06 | 2.8 | Gastrointestinal bleeding |
| 07 | 5.0 | Enrollment in another clinical trial |
| 08 | 2.5 | Initiation of systemic anticoagulation* |
| 09 | 1.6 | Reduction in creatinine clearance |
| 10 | 0.8 | Reduction in creatinine clearance |
| 11 | 3.0 | Reduction in creatinine clearance |
| 12 | 3.0 | Reduction in creatinine clearance |
| 13 | 0.1 | Volume overload |
| 14 | 2.9 | Initiation of systemic anticoagulation* |
Diflunisal was discontinued at the discretion of the treating physician to reduce the risk of bleeding with initiation of systemic anticoagulation.