Table 5:
Untreated n = 69 | Diflunisal n = 35 | p value | |||
---|---|---|---|---|---|
Baseline | 1 year follow up | Baseline | 1 year follow up | ||
NYHA class | 0.46 | ||||
I | 17 (24.6) | 3 (4.3) | 13 (37.1) | 9 (25.7) | |
II | 23 (33.3) | 2 (2.9) | 16 (45.7) | 18 (51.4) | |
III | 26 (37.7) | 19 (27.5) | 5 (14.3) | 6 (17.1) | |
eGFR, mL/min/1.73m2 | 53.2 ± 17.6 | 51.2 ± 20.1 | 67.3 ± 17.4 | 59.1 ± 16.7 | 0.03 |
BNP, pg/mL | 520.1 ± 296.1 | 595.8 ± 452.7 | 335.0 ± 365.6 | 300.5 ± 247.4 | 0.11 |
logBNP | 6.1 ± 0.7 | 6.1 ± 0.7 | 5.5 ± 0.8 | 5.4 ± 0.8 | 0.19 |
Troponin I, ng/mL | 0.2 ± 0.34 | 0.25 ± 0.6 | 0.1 ± 0.1 | 0.09 ± 0.07 | 0.12 |
LVEF, % | 45.0 ± 11.5 | 43.7 ± 12.9 | 53.1 ± 12.0 | 54.1 ± 10.2 | 0.27 |
Interventricular septal thickness, mm | 15.8 ± 2.3 | 16.6 ± 2.0 | 16.6 ± 2.7 | 17.2 ± 2.33 | 0.15 |
Posterior wall thickness, mm | 15.8 ± 2.4 | 16.3 ± 1.9 | 16.5 ± 2.2 | 16.7 ± 2.1 | 0.04 |
Continuous variables expressed as mean +/− standard deviation and categorical variables as number (%). p values reflect change differences between follow-up and baseline for treated versus untreated patients. eGFR was calculated using the CKD-Epi equation.