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. Author manuscript; available in PMC: 2023 Jan 1.
Published in final edited form as: Hum Pathol. 2021 Sep 27;119:15–27. doi: 10.1016/j.humpath.2021.09.009

Table 3.

Three case clusters identified by differential gene expression analysis.

Cluster 1 Cluster 2 Cluster 3 P
N 110 66 142
Gender M/F (ratio) 58/52 56/10 104/38 0.00001
Age (average ± SD) 55.5 ± 12 61.6 ± 13 60 ± 14 0.005
Pseudoglands 22 (20%) 43 (65%) 57 (40%) <0.00001
CTNNB1/APC mutations 14 (13%) 58 (88%) 25 (18%) <0.00001
AXIN mutations 20 (18%) 0 7 (5%) <0.00001
Classic beta-catenin morphology 15 (14%) 33 (50%) 28 (20%) <0.00001
CTNNB1 mutations and classic beta-catenin morphology 2 (2%) 28 (42%) 10 (7%) <0.00001
Intratumoral inflammation 37 (33%) 15 (23%) 37 (45%) 0.23
Ploidy (average ± SD) 2.9 ± 1 2.5 ± 0.8 2.4 ± 0.7 0.00013
TP53 mutations 44 (40%) 18 (26%) 44 (31%) 0.22
Combined CTNNB1 and TP53 mutations 6 (5%) 17 (26%) 2 (1%)
0 with clonal progression 8 with clonal progression
HBV infection 25 (23%) 21 (32%) 27 (19%) 0.12