FIGURE 5.

Mathematic modeling of ²²³Ra and 4B4 response. (A) Schematic representation of in silico tumor lesions in bone. White dot = interphase (IP) cell; red dot = apoptotic cell; cyan dot = mitotic cell. (B) In silico simulations of tumor growth by lesions of different sizes in control, 4B4-mAb, ²²³Ra, or ²²³Ra + 4B4 treated samples (data represent means of 10 simulations). i #= initial number of tumor cells. (C) Apoptotic index (probability of apoptosis/probability of mitosis for each agent).