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. 2022 Apr 7;152(7):1675–1689. doi: 10.1093/jn/nxac084

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© The Author(s) 2022. Published by Oxford University Press on behalf of the American Society for Nutrition.

This article is published and distributed under the terms of the Oxford University Press, Standard Journals Publication Model (https://academic.oup.com/journals/pages/open_access/funder_policies/chorus/standard_publication_model)

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Cross-sectional comparisons of plasma HDL subfractions measured by NMR in young (n = 30) and older (n = 54) adults (left column), and the effects of 6 mo of placebo (n = 22, middle column) and n–3-PUFA supplementation (n = 22, right column) on triglycerides (A), esterified cholesterol (B), free cholesterol (C), phospholipids (D), apoA-1 (E), and apoA-2 (F). HDL particles are numbered 1–4 in order of increasing density and decreasing size. A total of 5 participants dropped out after randomization (2 placebo, 3 n–3 PUFA). Data are shown as mean ± SD. *Significant (P value < 0.05) differences between young and older adults observed at baseline. ^ΩSignificant differences between treatment groups found by ANCOVA.