TABLE 2.

Main plasma lipoprotein parameters and particle number of young and older adults at baseline and older adults before and after 6 mo of placebo or n–3-PUFA supplementation¹

								Old n–3 PUFA vs. old placebo
			Old n–3 PUFA (n = 22)		Old placebo (n = 22)		Young vs. old	Adjusted mean
	Young (n = 30)	Old (n = 54)	Baseline	Follow-up	Baseline	Follow-up	P value	difference	95% CI	P value
TG, mg/dL	98.7 ± 44.5	99.7 ± 41.9	101 ± 41.7	77.1 ± 20.9	100 ± 47.5	94.3 ± 22.2	0.923	17.3	5.90, 28.7	0.004
Cholesterol, mg/dL	178 ± 32.2	190 ± 43.2	188 ± 35.1	185 ± 35.9	195 ± 54.9	195 ± 36.4	0.164	6.65	−12.6, 25.9	0.489
LDL cholesterol, mg/dL	96.4 ± 26.2	101 ± 28.8	99.5 ± 26.4	106 ± 29.8	104 ± 34.4	103 ± 27.7	0.484	−5.98	−18.1, 6.08	0.322
HDL cholesterol, mg/dL	51.8 ± 10.5	55.5 ± 14.2	54.4 ± 12.3	58.6 ± 13.5	57.1 ± 16.7	60.0 ± 13.9	0.208	−0.499	−6.15, 5.15	0.859
ApoA-1, mg/dL	137 ± 19.0	144 ± 25.5	143 ± 20.1	136 ± 19.3	146 ± 32.7	152 ± 24.9	0.183	14.9	3.56, 26.3	0.011
ApoA-2, mg/dL	29.1 ± 4.30	27.0 ± 5.20	27.3 ± 3.94	23.9 ± 3.05	26.9 ± 6.66	27.5 ± 5.39	0.063	3.74	1.21, 6.26	0.005
ApoB-100, mg/dL	72.0 ± 20.7	78.6 ± 19.4	78.0 ± 17.8	79.8 ± 20.5	80.3 ± 22.9	78.3 ± 15.9	0.149	−3.02	−11.2, 5.16	0.460
Particle number
ApoB, nmol/L	1310 ± 377	1430 ± 352	1420 ± 323	1450 ± 372	1460 ± 416	1420 ± 289	0.149	−54.9	−203, 93.7	0.460
VLDL, nmol/L	116 ± 51.1	129 ± 58.6	130 ± 57.7	103 ± 42.8	130 ± 65.9	121 ± 41.4	0.325	17.8	0.595, 35	0.043
IDL, nmol/L	51.0 ± 28.0	60.7 ± 29.1	59.1 ± 26.6	51.9 ± 30.8	64.5 ± 33.8	57.2 ± 29.5	0.143	2.49	−13.4, 18.3	0.752
LDL, nmol/L	1110 ± 325	1190 ± 311	1170 ± 289	1250 ± 360	1220 ± 369	1200 ± 280	0.296	−92.9	−226, 40.2	0.166
LDL-1, nmol/L	211 ± 39.2	253 ± 62.1	243 ± 62.6	198 ± 51.6	271 ± 66.8	269 ± 60.7	0.001	52.9	29.4, 76.3	<0.001
LDL-2, nmol/L	162 ± 36.6	176 ± 60.7	166 ± 53.9	138 ± 46.0	191 ± 69.4	194 ± 65.3	0.242	36.8	17.1, 56.4	0.001
LDL-3, nmol/L	178 ± 42.9	177 ± 60.0	169 ± 56.2	161 ± 55.3	186 ± 70.0	188 ± 65.8	0.956	14.2	−7.7, 35.9	0.199
LDL-4, nmol/L	166 ± 63.3	154 ± 68.5	153 ± 70.2	177 ± 81.0	152 ± 67.8	157 ± 69.8	0.440	−18.9	−48.2, 10.5	0.201
LDL-5, nmol/L	138 ± 96.4	134 ± 81.3	141 ± 80.2	203 ± 98.6	129 ± 90.3	115 ± 68.1	0.859	−80.0	−117, −43.3	<0.001
LDL-6, nmol/L	233 ± 139	252 ± 112	262 ± 111	329 ± 116	247 ± 134	221 ± 88.6	0.491	−102	−153, −49.9	<0.001

¹Values are mean ± SD unless otherwise indicated. TG, triglyceride.