TABLE 3.

Main plasma lipoprotein fractions of young and older adults at baseline and older adults before and after 6 mo of placebo or n–3-PUFA supplementation¹

								Old n–3 PUFA vs. old placebo
			Old n–3 PUFA (n = 22)		Old placebo (n = 22)		Young vs. old	Adjusted mean
	Young (n = 30)	Old (n = 54)	Baseline	Follow-up	Baseline	Follow-up	P value	difference	95% CI	P value
Triglycerides, VLDL, mg/dL	60.9 ± 35.1	53.8 ± 34.0	56.9 ± 35.6	42.4 ± 17.5	51.7 ± 37.2	46.0 ± 17.0	0.365	4.97	−3.8, 13.7	0.259
Triglycerides, IDL, mg/dL	8.28 ± 7.40	7.76 ± 6.75	7.96 ± 6.85	3.29 ± 2.63	7.98 ± 7.64	6.96 ± 3.10	0.740	3.67	2.03, 5.31	<0.001
Triglycerides, LDL, mg/dL	13.5 ± 4.96	15.9 ± 3.94	15.4 ± 3.61	17.7 ± 5.11	16.6 ± 4.74	15.9 ± 3.38	0.019	−2.66	−4.66, −0.664	0.010
Triglycerides, HDL, mg/dL	8.77 ± 2.71	10.1 ± 2.48	9.52 ± 1.83	9.36 ± 2.06	10.6 ± 3.05	10.6 ± 2.67	0.028	0.735	−0.582, 2.05	0.266
Cholesterol, VLDL, mg/dL	15.3 ± 7.96	16.3 ± 10.4	16.6 ± 10.1	10.9 ± 6.38	16.4 ± 12.01	14.6 ± 6.47	0.637	3.74	0.736, 6.75	0.016
Cholesterol, IDL, mg/dL	7.01 ± 4.65	8.04 ± 5.10	7.84 ± 4.55	6.05 ± 4.36	8.56 ± 6.00	6.89 ± 4.46	0.363	0.517	−1.77, 2.8	0.650
Cholesterol, LDL, mg/dL	96.4 ± 26.2	101 ± 28.8	99.5 ± 26.4	106 ± 29.8	104 ± 34.4	103 ± 27.7	0.484	−5.98	−18, 6.08	0.322
Cholesterol, HDL, mg/dL	51.8 ± 10.5	55.5 ± 14.2	54.4 ± 12.3	58.6 ± 13.5	57.1 ± 16.7	60.0 ± 13.9	0.208	−0.499	−6.15, 5.15	0.859
Free cholesterol, VLDL, mg/dL	7.35 ± 3.39	7.99 ± 3.96	8.12 ± 3.99	5.99 ± 2.44	8.02 ± 4.41	7.41 ± 2.58	0.461	1.46	0.365, 2.56	0.010
Free cholesterol, IDL, mg/dL	2.12 ± 1.36	2.36 ± 1.49	2.33 ± 1.36	1.50 ± 1.17	2.51 ± 1.69	2.04 ± 1.27	0.459	0.463	−0.182, 1.11	0.155
Free cholesterol, LDL, mg/dL	28.3 ± 6.41	30.0 ± 7.67	29.3 ± 7.08	31.0 ± 7.88	30.7 ± 9.19	30.5 ± 7.04	0.306	−1.32	−4.37, 1.74	0.390
Free cholesterol, HDL, mg/dL	11.5 ± 3.12	13.6 ± 3.41	12.9 ± 3.28	15.8 ± 3.75	14.1 ± 3.66	14.9 ± 3.56	0.006	−1.97	−3.23, −0.707	0.003
Phospholipids, VLDL, mg/dL	16.6 ± 7.40	16.3 ± 8.69	16.8 ± 9.05	13.3 ± 5.35	16.2 ± 9.47	14.8 ± 5.21	0.891	1.75	−0.575, 4.08	0.136
Phospholipids, IDL, mg/dL	4.67 ± 2.79	4.55 ± 2.86	4.47 ± 2.91	3.24 ± 1.88	4.80 ± 3.10	4.07 ± 1.88	0.855	0.768	−0.342, 1.88	0.170
Phospholipids, LDL, mg/dL	55.8 ± 12.4	58.8 ± 14.5	57.9 ± 13.1	60.5 ± 15.0	60.3 ± 17.4	60.3 ± 13.5	0.341	−1.92	−7.9, 4.05	0.519
Phospholipids, HDL, mg/dL	75.0 ± 15.9	79.8 ± 17.8	77.1 ± 16.2	76.4 ± 16.9	82.5 ± 20.3	86.9 ± 18.0	0.227	6.63	−0.631, 13.9	0.072
ApoA-1, HDL, mg/dL	135 ± 20.6	142 ± 26.4	140 ± 21.8	134 ± 22.3	144 ± 32.8	151 ± 26.4	0.178	14.5	3.07, 26	0.014
ApoA-2, HDL, mg/dL	29.6 ± 4.24	27.6 ± 5.16	28.0 ± 3.75	24.8 ± 3.00	27.5 ± 6.99	28.2 ± 5.21	0.072	3.55	1.14, 5.95	0.005
ApoB, VLDL, mg/dL	6.41 ± 2.81	7.10 ± 3.22	7.16 ± 3.19	5.69 ± 2.35	7.17 ± 3.61	6.68 ± 2.30	0.325	0.980	0.034, 1.92	0.043
ApoB, IDL, mg/dL	2.81 ± 1.54	3.34 ± 1.60	3.25 ± 1.45	2.85 ± 1.69	3.55 ± 1.88	3.15 ± 1.64	0.144	0.137	−0.733, 1.01	0.752
ApoB, LDL, mg/dL	61.1 ± 17.9	65.2 ± 17.1	64.2 ± 15.9	68.8 ± 19.8	67.0 ± 20.3	65.8 ± 15.4	0.296	−5.11	−12.4, 2.21	0.166

¹Values are mean ± SD unless otherwise indicated.