TABLE 5.
Plasma LDL subfractions of young and older adults at baseline and older adults before and after 6 mo of placebo or n–3-PUFA supplementation1
| Old n–3 PUFA vs. old placebo | ||||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Old n–3 PUFA (n = 22) | Old placebo (n = 22) | Young vs. old | Adjusted mean | |||||||
| Young (n = 30) | Old (n = 54) | Baseline | Follow-up | Baseline | Follow-up | P value | difference | 95% CI | P value | |
| Triglycerides, LDL-1, mg/dL | 4.82 ± 1.67 | 6.37 ± 1.49 | 6.11 ± 1.69 | 4.54 ± 1.41 | 6.85 ± 1.36 | 6.75 ± 1.36 | <0.001 | 1.67 | 1.14, 2.21 | <0.001 |
| Triglycerides, LDL-2, mg/dL | 1.93 ± 0.58 | 2.36 ± 0.70 | 2.19 ± 0.75 | 2.24 ± 0.61 | 2.56 ± 0.70 | 2.55 ± 0.66 | 0.006 | 0.058 | −0.187, 0.302 | 0.636 |
| Triglycerides, LDL-3, mg/dL | 2.06 ± 0.62 | 2.64 ± 0.54 | 2.48 ± 0.56 | 2.75 ± 0.61 | 2.88 ± 0.52 | 2.89 ± 0.47 | <0.001 | −0.198 | −0.375, −0.021 | 0.029 |
| Triglycerides, LDL-4, mg/dL | 1.47 ± 0.76 | 1.65 ± 0.70 | 1.55 ± 0.70 | 2.59 ± 1.03 | 1.70 ± 0.75 | 1.66 ± 0.61 | 0.292 | −1.05 | −1.42, −0.691 | <0.001 |
| Triglycerides, LDL-5, mg/dL | 1.47 ± 1.10 | 1.63 ± 0.98 | 1.60 ± 0.80 | 2.62 ± 1.17 | 1.63 ± 1.27 | 1.43 ± 0.75 | 0.517 | −1.20 | −1.67, −0.733 | <0.001 |
| Triglycerides, LDL-6, mg/dL | 2.25 ± 1.23 | 2.55 ± 1.14 | 2.67 ± 1.26 | 4.29 ± 1.36 | 2.47 ± 1.27 | 2.16 ± 0.80 | 0.268 | −2.05 | −2.65, −1.45 | <0.001 |
| Cholesterol, LDL-1, mg/dL | 22.5 ± 4.10 | 26.6 ± 7.20 | 25.6 ± 6.99 | 20.3 ± 5.49 | 28.3 ± 8.02 | 28.3 ± 6.94 | 0.006 | 6.44 | 3.61, 9.27 | <0.001 |
| Cholesterol, LDL-2, mg/dL | 16.1 ± 4.09 | 17.3 ± 6.68 | 16.3 ± 5.67 | 13.6 ± 5.21 | 18.8 ± 7.79 | 19.1 ± 7.36 | 0.369 | 3.49 | 1.32, 5.66 | 0.002 |
| Cholesterol, LDL-3, mg/dL | 17.0 ± 4.65 | 16.8 ± 6.21 | 16.0 ± 5.77 | 14.7 ± 5.53 | 17.6 ± 7.27 | 17.9 ± 6.89 | 0.844 | 1.94 | −0.34, 4.23 | 0.093 |
| Cholesterol, LDL-4, mg/dL | 14.8 ± 5.90 | 13.9 ± 6.17 | 13.8 ± 6.43 | 16.8 ± 7.13 | 13.7 ± 6.14 | 14.4 ± 6.52 | 0.536 | −2.29 | −4.91, 0.337 | 0.086 |
| Cholesterol, LDL-5, mg/dL | 11.4 ± 7.54 | 10.9 ± 6.56 | 11.5 ± 6.66 | 16.7 ± 8.02 | 10.4 ± 7.04 | 9.55 ± 5.58 | 0.777 | −6.35 | −9.25, −3.45 | <0.001 |
| Cholesterol, LDL-6, mg/dL | 15.3 ± 9.25 | 16.3 ± 7.64 | 17.1 ± 7.74 | 22.8 ± 8.07 | 16.0 ± 8.96 | 14.0 ± 6.00 | 0.582 | −8.29 | −11.9, −4.72 | <0.001 |
| Free cholesterol, LDL-1, mg/dL | 6.54 ± 1.25 | 7.81 ± 2.17 | 7.52 ± 2.02 | 6.03 ± 1.55 | 8.30 ± 2.53 | 8.26 ± 2.11 | 0.004 | 1.82 | 0.949, 2.70 | <0.001 |
| Free cholesterol, LDL-2, mg/dL | 4.66 ± 1.24 | 5.13 ± 2.13 | 4.86 ± 1.83 | 4.53 ± 1.59 | 5.54 ± 2.53 | 5.65 ± 2.20 | 0.271 | 0.624 | −0.043, 1.29 | 0.066 |
| Free cholesterol, LDL-3, mg/dL | 5.15 ± 1.27 | 5.43 ± 1.80 | 5.19 ± 1.78 | 5.52 ± 1.78 | 5.70 ± 2.02 | 5.82 ± 1.88 | 0.448 | −0.112 | −0.723, 0.499 | 0.714 |
| Free cholesterol, LDL-4, mg/dL | 4.34 ± 1.44 | 4.28 ± 1.50 | 4.23 ± 1.59 | 5.57 ± 1.83 | 4.25 ± 1.55 | 4.40 ± 1.59 | 0.869 | −1.19 | −1.85, −0.526 | 0.001 |
| Free cholesterol, LDL-5, mg/dL | 3.17 ± 1.88 | 3.11 ± 1.50 | 3.21 ± 1.55 | 4.81 ± 2.02 | 3.00 ± 1.64 | 2.80 ± 1.31 | 0.889 | −1.87 | −2.59, −1.15 | <0.001 |
| Free cholesterol, LDL-6, mg/dL | 4.01 ± 2.23 | 4.04 ± 1.84 | 4.19 ± 1.78 | 5.55 ± 1.92 | 3.97 ± 2.20 | 3.40 ± 1.50 | 0.940 | −2.04 | −2.94, −1.15 | <0.001 |
| Phospholipids, LDL-1, mg/dL | 12.8 ± 2.14 | 15.1 ± 3.66 | 14.5 ± 3.66 | 11.9 ± 2.86 | 16.0 ± 3.99 | 16.1 ± 3.52 | 0.002 | 3.29 | 1.89, 4.70 | <0.001 |
| Phospholipids, LDL-2, mg/dL | 9.12 ± 2.03 | 9.89 ± 3.41 | 9.37 ± 2.95 | 8.13 ± 2.67 | 10.7 ± 3.94 | 10.8 ± 3.71 | 0.260 | 1.69 | 0.632, 2.75 | 0.002 |
| Phospholipids, LDL-3, mg/dL | 9.50 ± 2.25 | 9.52 ± 3.09 | 9.09 ± 2.91 | 8.60 ± 2.77 | 10.0 ± 3.56 | 10.1 ± 3.42 | 0.973 | 0.883 | −0.224, 1.99 | 0.115 |
| Phospholipids, LDL-4, mg/dL | 8.37 ± 2.93 | 7.97 ± 3.18 | 7.90 ± 3.28 | 9.41 ± 3.61 | 7.86 ± 3.19 | 8.23 ± 3.24 | 0.568 | −1.14 | −2.50, 0.209 | 0.095 |
| Phospholipids, LDL-5, mg/dL | 6.42 ± 3.73 | 6.20 ± 3.32 | 6.45 ± 3.33 | 9.26 ± 3.99 | 5.93 ± 3.66 | 5.60 ± 2.77 | 0.783 | −3.28 | −4.72, −1.84 | <0.001 |
| Phospholipids, LDL-6, mg/dL | 9.04 ± 4.41 | 9.58 ± 3.75 | 9.90 ± 3.66 | 12.9 ± 3.99 | 9.46 ± 4.50 | 8.57 ± 2.86 | 0.555 | −4.11 | −5.89, −2.33 | <0.001 |
| ApoB, LDL-1, mg/dL | 11.6 ± 2.16 | 13.9 ± 3.41 | 13.3 ± 3.42 | 10.9 ± 2.86 | 14.9 ± 3.66 | 14.8 ± 3.33 | 0.001 | 2.91 | 1.62, 4.20 | <0.001 |
| ApoB, LDL-2, mg/dL | 8.91 ± 2.01 | 9.70 ± 3.33 | 9.15 ± 2.95 | 7.59 ± 2.53 | 10.5 ± 3.80 | 10.6 ± 3.61 | 0.242 | 2.02 | 0.942, 3.10 | <0.001 |
| ApoB, LDL-3, mg/dL | 9.79 ± 2.36 | 9.76 ± 3.30 | 9.29 ± 3.10 | 8.85 ± 3.05 | 10.2 ± 3.85 | 10.3 ± 3.61 | 0.956 | 0.778 | −0.421, 1.98 | 0.197 |
| ApoB, LDL-4, mg/dL | 9.15 ± 3.49 | 8.50 ± 3.77 | 8.41 ± 3.85 | 9.75 ± 4.46 | 8.34 ± 3.71 | 8.66 ± 3.85 | 0.439 | −1.04 | −2.65, 0.576 | 0.201 |
| ApoB, LDL-5, mg/dL | 7.59 ± 5.30 | 7.40 ± 4.47 | 7.74 ± 4.41 | 11.2 ± 5.44 | 7.10 ± 4.97 | 6.32 ± 3.75 | 0.859 | −4.40 | −6.42, −2.38 | <0.001 |
| ApoB, LDL-6, mg/dL | 12.8 ± 7.64 | 13.9 ± 6.16 | 14.4 ± 6.10 | 18.1 ± 6.38 | 13.6 ± 7.36 | 12.1 ± 4.88 | 0.491 | −5.58 | −8.43, −2.74 | <0.001 |
1
Values are mean ± SD unless otherwise indicated.