Table 3.

Treatment characteristics of patients experiencing grade 3–5 toxic effects after definitive radiotherapy for para-aortic recurrence

Grade of toxic effect	Type of toxic effect	Age, years	Location of para-aortic recurrence	GTV1 (cc)	Prior Pelvic RT	Surgical debulking	Neoadjuvant or adjuvant chemotherapy	Concurrent chemotherapy	Maximum dose (Gy) / fraction no.	Small bowel maximum / mean dose (Gy)
5	Duodenal fistula	59	L4–L5	31	No	No	Yes	Cisplatin	66 / 30	64.3 / 21.5
4	Small bowel fistula	63	T12	2.6	No	Yes	No	None	63 / 28	56.1 / 24.7
4	Small bowel perforation	54	L3–L4	15	No	Yes	Yes	Cisplatin	63.8 / 29	69.0 / 26.0
4	Duodenal fistula	78	L3	17	Yes	No	Yes	Cisplatin	61.6 / 28	61.1 / 23.5
3	Small bowel obstruction	53	L1–L2	10	Yes	Yes	Yes	Cisplatin	64.12 / 28	65 / 16.2

¹GTV, gross tumor volume.