Table 5.
The Association between the Significant Genotypes of “rs710521” with Bladder Cancer Risk
| rs710521 | Associations | Risk assessment | |||||
|---|---|---|---|---|---|---|---|
| AG | GG | aP. value | OR | 95% C.I | bP. value | ||
| n=69 | n=51 | ||||||
| Sex | Female | 12 (17.4%) | 6 (11.8%) | 0.3 | 1.579 | 0.550 - 4.535 | 0.4 |
| Male | 57 (82.6%) | 45 (88.2%) | |||||
| Bilhariziasis | Negative | 9 (13.0%) | 15 (29.4%) | 0.02* | 2.36 | 1.143 - 7.907 | 0.03* |
| Positive | 60 (87.0%) | 36 (70.6%) | |||||
| Smoker | No | 30 (43.5%) | 6 (11.8%) | 0.1 | 0.769 | 0.174 - 1.307 | 0.1 |
| Yes | 39 (56.5%) | 45 (88.2%) | |||||
| Clinical Ex. | T1 | 30 (43.5%) | 33 (64.7%) | 0.01* | 1.1 | 0.671 - 1.804 | 0.7 |
| T2 | 12 (17.4%) | 3 (5.9%) | 0.01* | 4 | 1.129 - 14.175 | 0.03* | |
| T3 | 27 (39.1%) | 15 (29.4%) | 0.04* | 1.9 | 0.958 - 3.384 | 0.05* | |
| Cytology | Negative | 21 (30.4%) | 15 (29.4%) | 0.5 | 1.05 | 0.476 - 2.316 | 0.9 |
| Positive | 48 (69.6%) | 36 (70.6%) | |||||
| Histopathological characteristics |
Scc | 15 (21.7%) | 9 (17.6%) | 0.4 | 1.296 | 0.517 - 3.251 | 0.6 |
| UC | 54 (78.3%) | 42 (82.4%) | |||||
| Stage | NMIBC | 3 (4.3%) | 3 (5.9%) | 0.5 | 1 | 0.202 - 4.955 | 0.9 |
| MIBC | 57 (82.6%) | 42 (82.4%) | 0.9 | 1.357 | 0.911 - 2.022 | 0.1 | |
| Superficial bladder cancer | 9 (13.0%) | 6 (11.8%) | 0.9 | 1.5 | 0.534 - 4.214 | 0.4 | |
| Serum Creatinine | Normal | 57 (82.6%) | 36 (70.6%) | 0.09 | 1.979 | 0.832 - 4.706 | 0.1 |
| High | 12 (17.4%) | 15 (29.4%) | |||||
| Lymph Node | Negative | 30 (43.5%) | 24 (47.1%) | 0.5 | 0.865 | 0.418 - 1.791 | 0.7 |
| Positive | 39 (56.5%) | 27 (52.9%) | |||||
| Tumor Grade | GI | 9 (13.0%) | 6 (11.8%) | 0.9 | 1.5 | 0.534 - 4.214 | 0.4 |
| GII | 18 (26.1%) | 12 (23.5%) | 0.7 | 1.5 | 0.723 - 3.114 | 0.3 | |
| GIII | 42 (60.9%) | 33 (64.7%) | 0.5 | 1.273 | 0.807 - 2.008 | 0.3 | |
SCC, squamous cell carcinoma; TCC, non-papillary transitional cell carcinoma; Ta, Superficial bladder cancer; NMIBC, Non muscle invasive bladder cancer; MIBC, Muscle invasive bladder cancer; OR, Odds Ratio; CI, Confidence Interval; *P value ≤ 0.05 significant; **P value ≤ 0.01 highly significant; aP. Value is depending on the X2 test, while bP. Value is depending onLogistic Regression analysis.