Table 4.
Detailed transplantation procedures and causes of death.
| Patient ID | Age at alloSCT (years) | HCT-CI score | Active infection type at time of alloSCT | HLA match | Conditioning | Stem cell source | T cell depletion | GVHD prophylaxis | Cause of death (days post SCT) | Organ toxicity (days post SCT) |
|---|---|---|---|---|---|---|---|---|---|---|
| UPN 1 | 20 | 0 | MSD | FB4 | BM | CsA-MTX | ||||
| UPN 2 | 26 | 1 | MSD | BuCy | BM | Alem | CsA-MTX | MOF (24) | Hepatic (SOS) grade 5 (20) | |
| UPN 3 | 17 | 1 | MSD | RFC | PBSC | TAC-MTX | ||||
| UPN 4 | 20 | 2 | Cryptosporidiosis | MMUD (mM DQ) | FB4 | PBSC | ATG | CsA-MMF | ||
| UPN 5 | 23 | 1 | MUD | FB4 | PBSC | ATG | CsA-MTX | |||
| UPN 6 | 22 | 2 | MUD | FB4 | PBSC | ATG | CsA-MTX | |||
| UPN 8 | 21 | 1 | Papovavirus. Moluscum | MSD | FB4 | BM | CsA-MMF | |||
| UPN 9 | 20 | 4 | Cryptosporidiosis | MMUD (mM A) | FB4 | PBSC | ATG | CsA-MTX | Hepatic grade 3 (4) | |
| UPN 11 | 30 | 2 | MSD | FB4 | PBSC | CsA-MTX | Pulmonary grade 3 (15) | |||
| UPN 12 | 18 | 4 | VZV | MSD | FB4 | PBSC | CsA-MMF | Refractory aGVHD (79) | ||
| UPN 13 | 28 | 2 | Bacterial cellulitis | MUD | FB4 | PBSC | CsA-MTX | |||
| UPN 14 | 23 | 2 | MUD | FB4 | PBSC | CsA-MTX | ||||
| UPN 15 | 22 | 5 | Cerebral IFI | HAPLO | Baltimore | PBSC | PTCy | CsA-MMF | PML (36) | |
| UPN 16 | 19 | 4 | Lung IFI | MUD | FB3 | BM | Alem | CsA-MMF | ||
| UPN 17 | 28 | 5 | MUD | FB3 | BM | Alem | CsA-MMF | |||
| UPN 18 | 23 | 1 | Bacterial pneumonia. Molluscum | MMUD (mM C) | FB3 | PBSC | ATG | CsA-MTX | ||
| UPN 19 | 35 | 4 | IFI. Bacterial pneumonia. Papovavirus. Moluscum | MUD | FB3 | BM | CsA-MTX | |||
| UPN 20 | 37 | 0 | MSD | FB4 | PBSC | ATG | CsA-MTX | |||
| UPN 21 | 32 | 0 | MUD | FB2 | PBSC | ATG | CsA-MTX | |||
| UPN 22 | 33 | 5 | MUD | FB2 | PBSC | ATG | CsA-MMF | Refractory cGVHD (285) | Hepatic grade 3 (1) | |
| UPN 23 | 37 | 6 | Cryptosporidiosis | MUD | FB2 | PBSC | ATG | TAC-MMF | Hepatic grade 3 (7) | |
| UPN 24 | 28 | 4 | HAPLO | T1B2F | PBSC | PTCy | CsA-MMF | Acute cardiac dysfunction (24) | Cardiac grade 5 (8) | |
| UPN 25 | 21 | 3 | lung and cardiac IFI | MUD | FB3 | PBSC | Alem | CsA-MMF | ||
| UPN 26 | 32 | 3 | Lung IFI | MSD | FB3 | BM | ATG | CsA-MMF | ||
| UPN 27 | 41 | 3 | MSD | FB4 | PBSC | ATG | CsA-MTX | Refractory aGVHD (52) | ||
| UPN 28 | 28 | 5 | Bacterial pneumonia | MUD | FB2 | PBSC | Alem | CsA-MMF | ||
| UPN 29 | 31 | 4 | Bacterial pneumonia | MUD | FB3 | PBSC | Alem | CsA-MMF | ||
| UPN 30 | 18 | 1 | Skin infection. Actynomycosis | MUD | FB3 | BM | Alem | CsA-MMF | ||
| UPN 31 | 28 | 2 | MUD | FB3 | PBSC | Alem | CsA-MMF | |||
| UPN 32 | 39 | 6 | MUD | FB3 | PBSC | Alem | CsA-MMF | |||
| UPN 33 | 36 | 4 | MMUD (mM DQ) | FB3 | BM | Alem | CsA-MMF | |||
| UPN 34 | 24 | 1 | Lung and thyroid IFI | MUD | FB3 | PBSC | Alem | CsA-MMF |
Alem alemtuzumab, ATG anti-thymo-globulin, B IV busulfan, BM bone marrow, C cyclophosphamide, CsA cyclosporine, F fluarabine, IFI invasive fungal infection, HCT-CI hematopoietic cell transplantation-comorbidity index, HAPLO sibling haplo-identical donor, MSD matched sibling donor, MUD matched related donor, MMUD mismatched unrelated donor, MMF mycophenolate mofetil, MTX methotrexate, MOF multi-organ failure, NA not applicable, PML Progressive multifocal leukoencephalopathy, PBSC peripheral blood stem cell, R Rituximab, SOS sinusoidal obstruction syndrome.