Fig. 7. Multiple phosphoinositide molecules associate with PH domains during simulation.

Plots of the number of PO4 (CG representation of position 1 phosphate) particles of PIP₂ and PIP₃ lipids within a 0.65-nm cutoff distance of the PH domain during simulations. The mean of 20 simulations for the AKT1, Asap1, btk, plcd1, p-rex1, and SKAP1 PH domains is plotted in dark red, with pale red shading representing the interval ±1 SD of the mean. The data for all simulated PH domains are shown in fig. S6.