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. 2022 Jun 22;13:926123. doi: 10.3389/fphar.2022.926123

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Copyright © 2022 Li, Lu, Zhang, Sai, Fan, Cheng and Liu.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Body weight changes of mice in each group (A) Body weight trend of female mice. WT: the control group of wild type mice treated with physiological saline solution for 2 weeks; 5×FAD: the model group of 5×FAD mice treated with physiological saline solution for 2 weeks; 5×FAD + Rg1: the positive control group of 5×FAD mice treated with 20 mg/kg/day ginsenoside Rg1 for 2 weeks; 5×FAD + LY01-H: the experimental group of 5×FAD mice with treated with 0.4 mg/kg/day LY01 for 2 weeks; 5×FAD + LY01-M: the experimental group of 5×FAD mice treated with 0.1 mg/kg/day LY01 for 2 weeks; 5×FAD + LY01-L: the experimental group of 5×FAD mice treated with 0.025 mg/kg/day LY01 for 2 weeks n = 4–5 (B) Body weight trend of male mice. WT: the control group of wild type mice treated with physiological saline solution for 5 weeks; 5×FAD: the model group of 5×FAD mice treated with physiological saline solution for 5 weeks; 5×FAD + Rg1: the positive control group of 5×FAD mice treated with 20 mg/kg/day ginsenoside Rg1 for 5 weeks; 5×FAD + LY01-H: the experimental group of 5×FAD mice treated with 0.4 mg/kg/day LY01 for 5 weeks; 5×FAD + LY01-M: the experimental group of 5×FAD mice treated with 0.1 mg/kg/day LY01 for 5 weeks; 5×FAD + LY01-L: the experimental group of 5×FAD mice treated with 0.025 mg/kg/day LY01 for 5 weeks n = 8–10. n. s, no significance. The results are expressed as means ± SD.