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. 2022 Jun 22;13:926123. doi: 10.3389/fphar.2022.926123

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Copyright © 2022 Li, Lu, Zhang, Sai, Fan, Cheng and Liu.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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The effect of LY01 on the number of new cells in the dentate gyrus area of 5×FAD mice (A) Representative images of new cells in the dentate gyrus of the hippocampus. The images show the result of female mice treated for 2 weeks and male mice treated for 5 weeks. The nuclei are labeled with 4′,6-diamidino-2-phenylindole (DAPI) (blue) and new cells are labeled with BrdU antibody (green) (B) The number of new cells in the dentate gyrus of female mice treated for 2 weeks **p < 0.01, ***p < 0.001 vs. 5×FAD; n = 3 (C) The number of new cells in the dentate gyrus of male mice treated for 5 weeks *p < 0.05 vs. 5×FAD; n = 4. WT: the control group of wild type mice treated with physiological saline solution; 5×FAD: the model group of 5×FAD mice treated with physiological saline solution; 5×FAD + LY01-H: the experimental group of 5×FAD mice treated with 0.4 mg/kg/day LY01. The results are expressed as means ± SD.