Extended Data Fig. 4 |. Distinct enhancer repertoires regulate transcriptional programs of the three CD8⁺ T cell subsets.

Venn diagram showing overlap of all chromatin-accessible regions (ChARs) detected by ATAC-seq. b, Bar plot showing the distance of ChARs to TSS. Left are ChARs with differential accessibility among the three CD8⁺ T cells subsets. Right are ChARs shared by the three subsets. c, Heatmap showing MSigDB pathway enrichment signatures in six enhancer peak sets as shown in Fig. 5c (Top). d, MA plot showing M value vs A value of the merged set of T_EFF cell and T_EXH cell enhancer peaks after normalization. Top 5,000 peaks are highlighted for T_EFF cells (cyan) and T_EXH cells (red). Dot plot showing the top 10 TFs whose motifs were significantly enriched in T_EFF cell-specific enhancers compared to T_EXH cell-specific enhancers.