Extended Data Fig. 7 |. BATF regulates chromatin accessibility of CD8⁺ T cells during chronic infection.

Gzmb⁻Cre⁺;Batf^+/+;Rosa^mT/mG (WT), Gzmb-Cre⁺;Batf^fl/+;Rosam^T/mG (BATF-HET), and Gzmb-Cre⁺;Batf^fl/fl;Rosa^mT/mG mice (BATF-KO) were used for this experiment. At 4 weeks post-LCMV Cl13 infection, CD8⁺CD44⁺GFP⁺ cells, which represent polyclonal LCMV-specific CD8⁺ T cells, were FACS sorted to perform ATAC-seq experiments. a, Venn diagram showing overlapping and unique enhancer regions in WT, BATF-HET, and BATF-KO CD8⁺ T cells b, Heatmap showing enhancer regions with differential accessibility. Scale bar representing Z-Score that is generated from log2 FPKM. Each replicate was an individual mouse.