Table 3.
Examples of active compounds isolated from natural extracts with ACE2 (S protein) inhibitory activity.
| Source | Family | Hits | Class of compounds | Bioactivities | Ref. |
|---|---|---|---|---|---|
| Camellia sinensis (Linnaeus) Kuntze | Theaceae | Epigallocatechin gallate (EGCG) | Catechin | IC50 = 2.47 µg/ml | Henss et al. (2021) |
| Caragana sinica (Buc'hoz) Rehder | Fabaceae | Kobophenol A | Stilbenoid | IC50 = 1.81 µM EC50 = 71.6 μM |
Gangadevi et al. (2021) |
| Glycyrrhiza glabra Linnaeus | Fabaceae | Glycyrrhizic acid | Triterpenes | IC50 = 22 µM | Yu et al. (2021) |
| Polygonum cuspidatum (Houttuyn) Ronse Decraene | Polygonaceae | Emodin 8-O-β-D-glucoside | Hydroxyanthraquinone glycoside | IC50 = 22.50 µmol/l | Chen et al. (2021b) |
| Rheum palmatum Linnaeus | Polygonaceae | Rhein | Anthraquinone | IC50 = 18.33 µmol/l | |
| Salvia miltiorrhiza Bunge | Lamiaceae | Tanshinone IIA, | Diterpene quinone | IC50 = 4.08 μM | Elebeedy et al. (2021) |
| Carnosic acid | Phenolic acids | IC50 = 15.37 μM | |||
| Rosmarinic acid | Diterpene | IC50 = 25.47 μM | |||
| Salvianolic acid B | Polyphenols | IC50 = 58.29 μM EC50 = 6.22 μM |
Elebeedy et al. (2021),Hu et al. (2021b) | ||
| Salvianolic acid C | EC50 = 10.14 μM | Hu et al. (2021b) | |||
| Salvianolic acid A | EC50 = 11.31 μM |