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. 2022 Jul 6;12(9):3456–3474. doi: 10.1016/j.apsb.2022.07.002

Figure 6.

Figure 6

Advanced strategies for vaginal mucosal delivery. (A and B) A microneedle array (proSMMA) was designed for vaccine delivery to the vaginal mucosa. Reprinted from Ref. 108. Copyright © 2017, Elsevier. (C) A squalene-assisted PEG-b-PLACL nanoemulsion was used to induce an antigen-specific vaginal mucosal immune response. CD11b/c+ and F4/80+ cells in vaginal mucosa were stained by (D) HE and (E) IHC after OVA/SQ@NE immunization. (F) OVA-specific IgG titers in serum and OVA-specific IgA levels in vaginal washes. Reprinted from Ref. 109. Copyright © 2021, Elsevier.