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Advanced strategies for ocular mucosal delivery. (A) The size, surface charge and surface coating of NPs have a decisive impact on the delivery abilities of eyedrop vaccines. (B) Membrane protein encapsulated in bacterial ghosts (BGs) could induce the production of Chlamydia trachomatis (Ct)-specific sIgA in tears by eyedrop inoculation. (C) The Fe3O4 NPs coated with glutamic acid, DNA vaccine pRSC-gD-IL-21 and PEI were developed against HSV-1 infection.
