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. 2022 Jul 2;17:2893–2905. doi: 10.2147/IJN.S363990

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© 2022 Chen et al.

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Investigation of biodistribution, sustainability and organ targeting characteristics of lipoplexes in mice following subcutaneous, intramuscular and intravenous administration. (A) Bioluminescence imaging of Balb/c nude mice after SC and IM injection of Fluc mRNA-LNP3. The images collected after transfection at time points of 12, 24, 48, 72 and 96 h. (B) Bioluminescence imaging of Balb/c nude mice after IV injection of Fluc mRNA-LNP3 and Fluc mRNA-LNP4 from two time points, 24 and 48 h, after transfection. (C) Bioluminescence imaging of liver, lung, kidney, spleen and skin in Balb/c mice after IV injection of Fluc mRNA-LNP3 and Fluc mRNA-LNP4, the results were collected 48 h later after transfection.

Abbreviations: SC, subcutaneous injection; IM, intramuscular injection; intravenous injection.