Figure 5.

Crystal structures of SARS-CoV, MERS-CoV and HCoV-NL63 M^pros in complex with PF-07304814. (A–C) Overall structures of SARS-CoV M^pro (A), MERS-CoV M^pro (B) and HCoV-NL63 M^pro (C) in complex with PF-07304814. Two protomers of M^pro are labeled. PF-07304814 is shown as sticks with the carbon atoms in magentas, oxygen atoms in red, nitrogen atoms in blue, and phosphorus atoms in orange. (D-F) The detailed interactions in the SARS-CoV M^pro-PF-07304814 complex (D), MERS-CoV M^pro-PF-07304814 complex (E), and HCoV-NL63 M^pro-PF-07304814 complex (F) are shown with the residues involved in inhibitor binding (within 3.5 Å) displayed as sticks. Hydrogen-bonding interactions are shown as black dashed lines.