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Enzymatic inhibition of GC376 against main protease of different coronaviruses. Inhibition of GC376 against main protease of SARS-CoV-2 (A), MERS-CoV (B), HCoV-HKU1 (C), and HCoV-NL63 (D). Main proteases were preincubated in the reaction buffer with various concentrations of GC376 at room temperature for 30 min before reacting with the FRET substrate The IC50 values was calculated using the GraphPad Prism software.
