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. 2022 Jun 30;6:e2100531. doi: 10.1200/PO.21.00531

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FIG A1. — Association of TMB with BRCAm frequency in MS-stable tumors (A) BRCA1/BRCA2 mutation prevalence binned on the basis of sample TMB (orange line) in MS-stable samples. Predicted monoallelic (red) and biallelic (blue) BRCAm prevalence was plotted on the same axes. (B) Fraction of BRCAm predicted as monoallelic (red) and biallelic (blue) in each TMB bin; analyses were limited to samples where allelic status could be determined. (C) gLOH distribution for biallelic BRCAm, monoallelic BRCAm, and BRCA1/2 wild-type samples in each TMB bin. gLOH, genome-wide loss of heterozygosity; MS, microsatellite; TMB, tumor mutational burden.