Table 1.

Differential metabolites of Model group, Sham group, and SXT-M group.

Part	No.	Metabolite name	Retention time(min)	Measured mean mass (Da)	Chemical formula	Normalized abundance (×105)
						Sham	Model	SXT-M
Cortex	1	Orthanilic acid	0.85	172.0213	C6H7NO3S	1.15	1.92▲▲▲	1.62∗∗
	2	Glutamine	0.87	145.0610	C5H10N2O3	21.50	30.72▲▲▲	24.54∗∗
	3	Humantenine	17.73	353.1976	C21H26N2O3	4.93	3.17▲▲▲	5.11∗∗∗
	4	Dodecylbenzenesulfonic acid	24.89	325.1818	C18H30O3S	53.40	64.05▲▲▲	51.95∗∗∗
	5	Dodecyl sulfate	24.40	265.1460	C12H26O4S	113.22	129.05▲▲	106.75∗∗∗
	6	Yohimbic acid	25.14	339.1974	C20H24N2O3	42.16	49.02▲▲▲	40.19∗∗∗
	7	S-sulforaphene	1.38	174.0010	C6H9NOS2	3.48	4.78▲▲	4.00∗
	8	3-Hydroxypropanoic acid	1.31	89.0240	C3H6O3	137.90	171.41▲▲	141.70∗∗
	9	Dihydroorotic acid	0.28	157.0108	C5H6N2O4	3.26	3.54▲	3.06∗∗∗
	10	Glyceric acid	0.76	105.0166	C3H6O4	2.49	2.69▲	2.39∗∗
	11	Embelin	24.86	293.1771	C17H26O4	81.56	93.37▲▲	77.97∗∗∗
	12	Etidronate	23.68	204.9879	C2H8O7P2	1.62	1.80▲	1.45∗∗∗
	13	Threonic acid	23.14	135.0102	C4H8O5	1.45	1.59▲▲	1.45∗∗
Hippocampus	1	Fumaric acid	1.29	115.0030	C4H4O4	0.32	0.28▲	0.32∗
	2	Embelin	13.24	293.1733	C17H26O4	12.01	6.18▲▲▲	9.10∗∗∗
	3	Glutamic acid	14.55	146.0348	C5H9NO4	5.40	3.69▲▲	5.25∗∗
	4	Butylparaben	12.04	193.0854	C11H14O3	3.26	2.04▲▲▲	2.90∗∗∗
	5	2,4-Dihydroxybenzophenone	0.84	213.0473	C13H10O3	4.11	6.39▲▲▲	5.01∗

The model group was compared with the sham group, ^▲P < 0.05, ^▲▲P < 0.01, ^▲▲▲P < 0.001. The SXT-M group was compared with the model group: ^∗P < 0.05, ^∗∗P < 0.01, and ^∗∗∗P < 0.001.