Table 2.

Combined diagnostic models of routine indicators.

Models	Variables	AUC	Diagnostic efficacy	Ref
FLI	BMI, waist, TG, GGT	NAFLD: 0.84	NASH: cut-off: <30 and ≥60, SEN: 87%, SPE: 86%	[38]
HIS	ALT/AST, BMI, gender, diabetes	NAFLD: 0.81	NAFLD: cut-off: <30 and >36, SEN: 92.5%, SPE: 92.4%	[39]
NSS	Age, BMI, TG, FPG, ALT/AST, UA	Men: 0.83; women: 0.86	Men: cut-off: 33, SEN: 79.86%, SPE: 66.13%; women: cut-off: 29, SEN: 89.39%, SPE: 68.98%	[40]
ION	WHR, TG, ALT, HOMA	NAFLD: 0.77	NAFLD: cut-off: <11, SEN: 81%, SPE: 56%; cut-off: ≥22, SEN: 60%, SPE: 82%	[41]
NAFLD liver fat score	MS, diabetes, insulin, AST, AST/ALT	NAFLD: 0.87	NAFLD: cut-off: -0.640, SEN: 86%, SPE: 71%	[42]
HAIR score	HBP, ALT, insulin, GLU	NASH: 0.68	NASH: cut-off: 3, SEN: 57%, SPE: 77%	[43]
SteatoTest-2	A2M, ApoA1, HP, GGT, TC, GLU, ALT, AST, age, gender	SS: 0.68	SS: SEN: 95.5%, PPV: 97.0%	[44]
NASHTest-2	A2M, ApoA1, HP, TBIL, GGT, TC, TG	NASH: 0.59	NASH: SEN: 83.3%, SPE: 37.5%	[44]

NAFLD: nonalcoholic fatty liver disease; NASH: nonalcoholic steatohepatitis; SS: simple steatosis; AUC: area under the curve; SEN: sensitivity; SPE: specificity; BMI: body mass index; TG: triglycerides; GGT: γ-glutamyl transpeptidase; ALT: alanine aminotransferase; AST: aspartate aminotransferase; FPG: fasting glucose; UA: uric acid; WHR: waist-hip ratio; HOMA: homeostasis model assessment; MS: metabolic syndrome; HBP: high blood pressure; GLU: glucose; A2M: alpha-2 macroglobulin; APOA1: apolipoprotein A1; HP: haptoglobin; TC: total cholesterol; TBIL: total bilirubin.