| Intramuscular testosterone |
Every 1 or 2 weeks |
Better compliance than topical due to less frequent dosage |
Fluctuating testosterone levels, injection complications |
| Subcutaneous testosterone |
Bi-weekly or weekly |
Better compliance than topical, with a shorter needle than IM forms |
Fluctuating testosterone levels, not approved in USA |
| Testosterone gel |
Daily |
Ease of application, and less variation in testosterone levels |
Slower masculinization than IM or SC, potential transfer with contact |
| Testosterone patch |
Daily |
Ease of application, and less variation in testosterone levels |
Skin irritation, and lower testosterone levels than gel |
