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. 2022 Mar 28;15(4):668–682. doi: 10.1038/s41385-022-00503-0

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© The Author(s) 2022

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 2 — a Flow cytometric analysis of PB/PC defined as CD138⁺/TACI⁺ for SP, BM, Blood, mLN and PP or CD138⁺/ENPP1⁺ for colon LP (cLP) divided into IgA⁺, IgM⁺ and IgA⁻/IgM⁻ PB/PC isotypes of of WT cre+ control (upper plots) and KLF2 cKO (lower plots) mice; numbers indicate the percentage of cells in the respective gates; b bar charts show the arithmetic mean with SEM of CD138⁺/TACI⁺ PB/PC frequencies (left diagram), frequencies of TACI⁺/CD138⁺/IgA⁺ (mid diagram) and total cell numbers of TACI⁺/CD138⁺/IgA⁺ (right diagram) from SP, BM, mLN, PP and the blood from WT cre+ mice (white circles, white bars) and KLF2 cKO mice (black squares, gray bars); N = 2 experiments with n = 6–7 (blood and PP) and n = 12 (SP, BM, mLN) mice; statistical analyses were performed for genotype comparison by unpaired t-test. For cLP: bar charts show the arithmetic mean with SEM of CD138⁺/ENPP1⁺ PB/PC frequencies (left diagram) and frequencies of IgA⁺ PB/PC (right diagram) of KLF2 cKO (gray bars, black squares) and WT cre+ control (white bars, white circles) mice; n = 4; statistics were calculated by using an unpaired t-test. FI fluorescence intensity, BM bone marrow, SP spleen, mLN mesenteric lymph nodes, PP Peyer’s patches, cLP colon lamina propria, ns non-significant; *p < 0.05; **p < 0.01; ***p < 0.005; ****p < 0.001.