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. 2022 Mar 21;15(4):730–744. doi: 10.1038/s41385-022-00495-x

Fig. 9. Signaling relationships among immune cells during LPS-induced lung injury compared to combined TNFα and IL-1R blockade.

Fig. 9

a Major signaling pathways changed between LPS and combination (+IL-1RA and anti-TNF) blockade (Combo). b Differential interactions strength of cell signaling relationships between immune cells. Signals increased in LPS are shown in red, those increased in combination blockade in blue. c Major signaling ligands involved in monocytes/macrophages and neutrophils comparing LPS and combination blockade. Comparison of major incoming and outgoing signals in neutrophils (d) and monocytes/macrophages (e) during LPS or LPS+ combination blockade. All analyses were performed with CellChat (see Methods).