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. 2022 Apr 21;607(7917):128–134. doi: 10.1038/s41586-022-04778-y

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© The Author(s) 2022

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Extended Data Fig. 5 — a, Graphs show half-maximal concentration (EC₅₀) of n = 459 monoclonal antibodies measured by ELISA against Wuhan-Hu-1 RBD after prime⁶, 1.3- and 5-months post-Vax2^5,6, and 1 month after Vax3. b, Graph showing EC50 of n = 459 monoclonal antibodies as categorized as either persisting clones detected at multiple time points, unique clones where sequences were clonally expanded but detected at a single time point, or singlets where mAbs were derived from sequences detected once at a single time point. c-d, EC₅₀ (c) or IC₅₀ neutralizing activity (d) of n = 246 monoclonal antibodies derived from shared clones only. Lines connect the related clones at the indicated time point. Red bars and numbers in a, and b, indicate geometric mean values. Statistical significance was determined by two-tailed Kruskal Wallis test with subsequent Dunn’s multiple comparisons. All experiments were performed at least twice.