Table 2.

Role of histone acetyltransferases (HATs) and histone deacetylases (HDACs) during neurogenesis

	Enzyme	Model	Effect on neurogenesis	Histones	Target genes	Refs.
HAT	CBP	Mouse embryonic brain	Embryonic ↑	H3K9/K14ac	α1-tubulin, Gfap, Mbp	68
	CBP/p300	NSC from mouse embryos	Embryonic ↑		Neuro D	69
	CBP	Hippocampus of CBP-deficient mice under environmental enrichment	Adult ↑	AcH2B, AcH3	Lif, Neurog1, Dcx, Nes, NpY	70
	KAT6B	Mutant KAT6B mice	Embryonic ↑			71
	KAT6B	KAT6B-deficient mice, SVZ cells isolated from KAT6B-deficient mice	Adult ↑			72
	KAT8	Cerebrum-specific KO mice using Emx1-Cre	Embryonic ↑	H4K16ac		73
HDAC	HDAC1/HDAC2	Conditional KO mice using GFAP-Cre, KO neuronal precursors	Embryonic ↑			81
		Conditional KO mice using Emx1-Cre	Embryonic ↑			82
		Conditional KO mice using Nestin-Cre	Embryonic ↑			84
	HDAC1	Mouse embryonic brain, mouse ESC	Embryonic ↑	H3K9ac	Sox2	85
		Deletion of HDAC1 by viral infection of Hippocampal NSCs	Adult ↑			92
	HDAC2	Conditional KO mice using Nestin-Cre	Embryonic ↑	H3K9ac	Prkcd	84
		HDAC2 mutant mice, conditional deletion of HDAC2 in adult NSCs	Adult ↑			90
	HDAC3	Conditional KO mice using Nestin-Cre	Embryonic ↑			86
		Cerebrum-specific KO mice using Emx1-Cre	Embryonic ↑			87
	HDAC4	Conditional KO mice using Thy1-cre and Nestin-cre	N/e			88
	HDAC5	Hippocampal NSCs from adult rat HCN cells	Adult ↓		MEF2 target genes	96
	SIRT1	Cortical NPC from mouse embryos	Embryonic ↓	H3K9ac	Mash1	97
		Neuro 2A (N2a), a mouse neural crest-derived cell line	Embryonic ↓			99
		SVZ and Hippocampal Neural Precursors, conditional KO mice using Nestin-Cre	Adult ↓			98
	SIRT6	Mice with a heterozygous Sirt6 overexpression	Adult ↑			100

↑ Increase, ↓ decrease, n/e no effect