Table 3.

Role of histone methyltransferases (HMTs) and histone demethylases (HDMs) during neurogenesis

	Enzyme	Model	Effect on neurogenesis	Histones	Target genes	Refs.
HMT	MLL1	Conditional KO mice using GFAP-Cre, NSCs from SVZ	Adult ↑	H3K4me3	Dlx2	103
	SETD1A	Mouse embryonic NSCs	Embryonic ↑	H3K4me3	β-catenin	104
	SETD5	Knockdown by in utero electroporation to embryos, NSCs from embryos, Setd5 mutant mice	Embryonic ↑	H3K36me3		105
	EZH2	Conditional KO mice using Emx1-Cre	Embryonic ↑			106
		Conditional KO mice using Pax7-Cre	Embryonic ↑	H3K27me3		107
		Conditional KO mice using hGFAP-CRE, SVZ NSCs	Adult ↑	H3K27me3	Ink4a/Arf and Olig2	108
		Conditional KO mice using Nestin-Cre	Adult ↑	H3K27me3		109
	SETDB1	Conditional KO mice using Emx1-Cre or Nestin-Cre, embryonic NPCs	Embryonic ↑	H3K9me3	Sox9, IAP	110
	DOT1L	Conditional KO mice using Foxg1-Cre, Emx1-Cre, Nestin-CreER(T2)/R26R-(YFP)	Embryonic ↑	H3K79me2	Satb2	113
	PRMT6	PRMT6 KO NT2/D1 cells by CRISPR/Cas9 genome editing, constitutive KO mice	Embryonic ↑	H3R2me2a		114
HDM	LSD1	Mouse embryonic cortex	Embryonic ↑	H3K4me1	Dlx2, Shh	117
		Human fetal NSCs	Embryonic ↑	H3K4me2	HELY	119
	LSD1 + 8a	Rat cortical neuron	Embryonic ↑			120
	KDM5B	NSCs isolated from adult SVZ	Adult ↓	H3K4me3	Reln	125
	KDM5C	Zebra-fish development, rat primary cerebellar granule neurons	Embryonic ↑	H3K4me3		124
	KDM6B	Differentiation of mouse embryonic stem cells into NSCs	Embryonic ↑	H3K27me3	Nestin	126
		Rat neural stem cell	Embryonic ↑		Dlx5	127
		Targeted Jmjd3-deletion to SVZ NSCs in adult mice by stereotactic injection of the Ad:GFAP-Cre adenovirus into the SVZ	Adult ↑	H3K27me3	Dlx2	128
	PHF2	Mouse embryonic NSCs, chicken embryo spinal cords	Embryonic ↑	H3K9me2		129

↑ Increase, ↓ decrease