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. 2022 Jul 6;13(7):583. doi: 10.1038/s41419-022-05047-6

Fig. 1. Pol β deficiency exacerbates disease severity in CIA mice.

Fig. 1

A, B Pol β expression in CD4+ T cells (GEO database: GSE56649) and PBMCs from active RA patients and healthy donors. All data are means ± SD from at least six independent samples. *P < 0.05, **P < 0.01. Student’s t-test (A, B). C qRT-PCR analysis of Pol β mRNA expression in the PBMCs of CIA mice. D The levels of Pol β mRNA in CIA mice’s ankles were measured by qRT-PCR. Data present mean ± SD from at least 6 mice, *P < 0.05, **P < 0.01, ***P < 0.001, two-way ANOVA. E The levels of Pol β protein in CIA mice’s ankles were measured by Western blotting. Data are representative blot of three independent experiments. Pol β deficiency exacerbates disease severity in CIA mice. F, G The clinical arthritic scores of CIA mice. Data present mean ± SD from at least 6 mice, ***P < 0.001, two-way ANOVA. H, I Macroscopic images of CIA mice, images were taken on Day 49 before the mice were sacrificed. J, K Histopathological analysis of CIA mice. Ankle joints were stained with H&E. Arrow indicates inflammatory cell infiltration. Scale bar, 500 μm. L, M The cartilage damage of CIA mice. Data present mean ± SD from at least 6 mice, *P < 0.05, **P < 0.01, ***P < 0.001, one-way ANOVA.